POS0662 THE SOCIOECONOMIC PROFILE OF PATIENTS WITH RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS IS ASSOCIATED WITH THE SEVERITY OF THE DISEASE AND WITH THE PERMANENT DISABILITY. A CLUSTER ANALYSIS IN A NATIONAL SPANISH REGISTRY

Background Previous studies have demonstrated that male gender and higher level of education are independently associated with a lower hazard sick leave in patients axial Spondyloarthritis (axSpA), while female has disadvantageous effect on employment. However, few identified socio-economic profiles their association the severity disease disability. Objectives a) to identify clusters r-axSpA according characteristics; b) evaluate these permanent Methods REGISPONSER (Spanish Registry Spondyloarthritis) was cross-sectional multicentre study including Spanish spondyloarthritis (SpA) ESSG criteria. Patients considered by treating rheumatologist as suffering from radiographic axSpA (r-axSpA) or ankylosing spondylitis (AS) were included this specific analysis. A cluster analysis conducted using information sociodemographic (age, sex, race, marital status, education) socioeconomic characteristics (employment, profession, housing conditions social level). Multiple correspondence analyses k-means clustering methods used. The clinical characteristics, burden disability compared between different adjusting for duration. Results total 866 Two found (Table 1). Cluster 1 (n=476) showed profile predominantly married, secondary/elementary studies, unemployed/housekeepers, nonskilled workers, good deficient low-middle level. On other hand, 2 (n=479) university/bachelor employed, university/technician professions, optimal upper-middle In terms disease, after duration, older age at diagnosis (37.9 vs. 32.6), longer delay (7.8 6.8 years), body mass index (27.6 25.9) greater structural damage comparison (BASRI (5.7 4.6) BASRI cervical (6.9 5.7)). No differences regarding smoking, peripheral extra-musculoskeletal manifestations. access biologic modified antirheumatic drugs (bDMARDs) similar two groups (30.6% 27.5%, p=0.376, 2, respectively). prevalence duration [30.8% 13.2%, OR 2.58 (95%CI 1.76 - 3.83), p<0.001]. Conclusion This suggests may implications despite use bDMARDs. Table 1. Comparison clusters. N = 476 390 Sex Female 75.2% 74.1% Race white Others 98.5% 99.7% Married single/ divorced/ widowed 81.5% 71.0% University/ bachelor secondary/ elementary studies/ illiterate 4.4% 73.1% Employed/ retired unemployed/ housekeeper 51.0% 67.4% technician profession employee/ skilled/ worker 0.4% 49.0% Luxury/ good/ deficient/ inadequate 27.9% 65.9% Upper/ Upper-middle/ middle low-middle/ underclass 8.4% 99.5% REFERENCES: NIL. Acknowledgements: Disclosure Interests Clementina López-Medina Speakers bureau: UCB, Eli Lilly, Abbvie, Janssen, Novartis MSD, Consultant of: Grant/research support from: Abbvie Desiree Ruiz: None declared, María Ángeles Puche Larrubia: Lourdes Ladehesa Pineda: M. Carmen Ábalos-Aguilera: Font Ugalde Pilar: Alejandro Escudero Contreras Galapagos, Eduardo Collantes Estevez Lilly Novartis, Lilly.